2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

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DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-111965
    PF-06647263
    PF-06647263 is an ADC targeting EFNA4, consisting of EFNA4 Antibody (HY-P991109), ADC toxin Calicheamicin (HY-19609) and a linker. PF-06647263 exhibits anti-tumor activity and induces significant tumor regression in TNBC xenografts.
    PF-06647263
  • HY-17420AS
    Cyclophosphamide-d8 hydrate
    Cyclophosphamide-d8 (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
    Cyclophosphamide-d<sub>8</sub> hydrate
  • HY-17419S2
    Ifosfamide-d4-1
    Ifosfamide-d4-1 is deuterium-labeled Ifosfamide (HY-17419).
    Ifosfamide-d<sub>4</sub>-1
  • HY-139635
    Anticancer agent 11
    		Inducer
    Anticancer agent 11 is a broad-spectrum anticancer agent that inhibits angiogenesis and induces DNA cross-links.
    Anticancer agent 11
  • HY-175004
    PBD dimer-4
    PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types.
    PBD dimer-4
  • HY-160063
    SW1 aptamer sodium
    SW1 aptamer sodium is a high-affinity DNA aptamer (Kd: 123.62 nM) that targets liver cancer SMMC-7721 cells and targets intracellular components within the nucleus. SW1 aptamer sodium can also identify various other types of cancer cells and tissues, serving as an effective molecular probe for clinical cancer diagnosis.
    SW1 aptamer sodium
  • HY-B1157R
    Trioxsalen (Standard)
    Trioxsalen (Standard) is the analytical standard of Trioxsalen. This product is intended for research and analytical applications. Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation.
    Trioxsalen (Standard)
  • HY-W740674
    4-Ketocyclophosphamide
    		Control
    4-Ketocyclophosphamide is an inactive metabolite of the alkylating agent Cyclophosphamide (HY-17420).
    4-Ketocyclophosphamide
  • HY-N15366
    N-Acetoxy-IQ
    N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA adducts. N-Acetoxy-IQ is promising for research of cancers.
    N-Acetoxy-IQ
  • HY-127005
    Ritrosulfan
    Ritrosulfan is a member of the alkylating sugar alcohol. Ritrosulfan is a hydrolyzing alkylating agent with anti-tumor activity.
    Ritrosulfan
  • HY-W587524
    Carboxyphosphamide
    		Control
    Carboxyphosphamide is an inactive metabolite of the alkylating agent Cyclophosphamide (HY-17420).
    Carboxyphosphamide
  • HY-130547A
    BS2G Crosslinker
    BS2G Crosslinker
  • HY-16398R
    Pipobroman (Standard)
    Pipobroman (Standard) is the analytical standard of Pipobroman. This product is intended for research and analytical applications. Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al.
    Pipobroman (Standard)
  • HY-159075
    N-Sulfosuccinimidyl iodoacetate sodium
    N-Sulfosuccinimidyl iodoacetate sodium
  • HY-126160
    CB10-277
    CB10-277 is a Dacarbazine (HY-B0078) analog that mediates alkylation of guanine residues at the O6 position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma.
    CB10-277
  • HY-16117A
    Brostallicin
    Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity.
    Brostallicin
  • HY-13543R
    Tretazicar (Standard)
    Tretazicar (Standard) is the analytical standard of Tretazicar. This product is intended for research and analytical applications. Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1).
    Tretazicar (Standard)
  • HY-34477R
    2-Iodoacetamide (Standard)
    2-Iodoacetamide (Standard) is the analytical standard of 2-Iodoacetamide. This product is intended for research and analytical applications. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics.
    2-Iodoacetamide (Standard)
  • HY-W011123
    N-Succinimidyl 4-[4-maleimidophenyl]butyrate
    N-Succinimidyl 4-[4-maleimidophenyl]butyrate is a crosslinking agent.
    N-Succinimidyl 4-[4-maleimidophenyl]butyrate
  • HY-34758R
    N-Nitroso-N-methylurea (Standard)
    N-Nitroso-N-methylurea (Standard) is the analytical standard of N-Nitroso-N-methylurea. This product is intended for research and analytical applications. N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane.
    N-Nitroso-N-methylurea (Standard)
Cat. No. Product Name / Synonyms Application Reactivity